AUTOANTIBODIES TO BRAIN GLUTAMIC ACID DECARBOXYLASE IN CHILDREN WITH NEWLY DIAGNOSED IDDM
نویسندگان
چکیده
منابع مشابه
Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus.
The cause of downbeat nystagmus (DBN) remains undiagnosed in about 40% of patients. This paper reports the presence of antiglutamic acid decarboxylase antibodies (GAD-Ab) in a patient with DBN. Antibodies against GABAergic neurons located in the vestibular complex may induce chemical denervation of the floccular neurons, which normally suppress the peripheral imbalance between vertical semicirc...
متن کاملTwo distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target different epitopes.
Although most individuals with insulin-dependent diabetes mellitus (IDDM) have autoantibodies to glutamic acid decarboxylase (GAD), antibodies to GAD are also present in some individuals with a low risk of developing diabetes. The GAD autoantibodies of IDDM are specific for the GAD65 isoform, do not bind denatured GAD protein, and target epitope(s) dependent on conformation of the protein. Howe...
متن کاملEncephalitis associated with glutamic acid decarboxylase autoantibodies in a child: a treatable condition?
OBJECTIVE To increase the recognition of glutamic acid decarboxylase autoantibodies-related encephalitis in childhood. DESIGN Case report and review of the literature. PATIENT A 6-year-old girl who had developed refractory seizures, developmental regression, and type 1 diabetes mellitus at age 25 months. INTERVENTIONS Blood analysis, electroencephalogram, cerebral magnetic resonance imagi...
متن کاملMonoclonal antibodies to glutamic acid decarboxylase.
Five monoclonal antibodies that recognize chicken brain glutamic acid decarboxylase (GAD) have been selected and designated GAD-1 to -5. GAD-1 to -5 were selected on the basis of their ability to immunoprecipitate active GAD from crude brain extracts. GAD-1 recognizes an epitope that is conserved in many vertebrates; the epitope recognized by GAD-5 is restricted to the chicken. Radioimmunoassay...
متن کاملNeural conduction in visual pathways in newly-diagnosed IDDM patients.
OBJECTIVES Visual evoked potentials (VEPs) show abnormal responses in newly-diagnosed insulin-dependent diabetic (IDDM) patients. Electrophysiological methods allow one to dissect and explore different structures contributing to neural conduction in the visual pathways. The aim of our work was to assess whether the VEP abnormalities are due to impaired function of the retinal layers and/or a de...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1993
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199305001-00417